SIGLEC8

Across TCGA patient cohorts, SIGLEC8 mutation is significantly associated with the RNA expression of many other genes, with 3,839 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC8-associated genes across cancer lineages are USP9YP10, ZIK1P1, and TRIM51GP. Each is linked with SIGLEC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIGLEC8-to-partner and partner-to-SIGLEC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP9YP10 grouped by SIGLEC8-low versus SIGLEC8-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC8→partner) and Y-score (partner→SIGLEC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	USP9YP10 →	+0.114	+4.857	<.001	.005	3	3
UCEC	ZIK1P1 →	+0.079	+1.983	<.001	<.001	3	3
LUSC	TRIM51GP →	+0.357	+2.813	<.001	.002	3	3
SKCM	RPS12P15 →	+0.045	+1.884	.004	.006	3	3
GBM	RNU6-928P →	+0.533	+4.857	<.001	.005	3	2
GBM	MIR6859-2 →	+1.020	+4.203	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,839 associations by consensus.

USP9YP10 by SIGLEC8 expression — GBM

Explore this box plot interactively →