SIGLEC8

Across TCGA pan-cancer cohorts, SIGLEC8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SIGLEC8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SIGLEC8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SIGLEC8 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and KICH are the cancer types where SIGLEC8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIGLEC8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.891	<.001	12	view →
COAD	Female	II,III,IV	−1.186	<.001	11	view →
KICH	Female	All	+1.528	<.001	10	view →
KIRP	Male	All	+2.136	<.001	9	view →
THCA	All	II,III,IV	+0.457	.001	7	view →
BRCA	All	All	+0.392	<.001	6	view →
LUSC	Male	All	−0.832	<.001	4	view →
LUAD	All	All	−0.484	.003	4	view →
READ	All	All	−1.113	.005	2	view →
UCEC	All	All	−0.549	<.001	2	view →
BLCA	All	All	−0.504	.010	2	view →
LIHC	Male	All	−0.468	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SIGLEC8–KIRC

Open the KIRC breakdown →