SIGLEC24P

Across TCGA patient cohorts, SIGLEC24P RNA expression is significantly associated with the go_rna of many other GO terms, with 6,140 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SIGLEC24P-associated GO terms across cancer lineages are rRNA methylation, Microtubule-based transport, and Negative regulation of growth. Each is linked with SIGLEC24P in more than 7 cancer types. Because this analysis shows association rather than direction, both SIGLEC24P-to-partner and partner-to-SIGLEC24P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA methylation grouped by SIGLEC24P-low versus SIGLEC24P-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC24P→partner) and Y-score (partner→SIGLEC24P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	rRNA methylation →	+0.082	+0.112	<.001	<.001	3	8
STAD	Microtubule-based transport →	+0.066	+0.102	<.001	<.001	3	7
STAD	Negative regulation of growth →	+0.070	+0.121	<.001	<.001	3	7
STAD	rRNA 3'-end processing →	+0.083	+0.098	<.001	<.001	3	7
STAD	Regulation of dephosphorylation →	+0.095	+0.107	<.001	<.001	3	7
ESCA	Cellular respiration →	+0.119	+0.040	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,140 associations by consensus.

rRNA methylation by SIGLEC24P expression — STAD

Explore this box plot interactively →