SIGLEC24P

Across TCGA pan-cancer cohorts, SIGLEC24P RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated SIGLEC24P data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SIGLEC24P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SIGLEC24P expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

KIRC, LIHC, and THCA are the cancer types where SIGLEC24P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.750	0.814	.008	72	view →
LIHC	OS	Tertile	III,IV	0.059	0.738	<.001	66	view →
THCA	DFS	Tertile	IV	0.126	0.805	.002	57	view →
GBM	DFS	Tertile	All	0.080	0.260	.002	36	view →
CHOL	OS	Tertile	All	0.089	0.727	.001	27	view →
THYM	DFS	Tertile	All	0.134	0.871	<.001	18	view →
SKCM	DFS	Tertile	All	0.078	0.213	.004	18	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	18	view →
STAD	OS	Tertile	IV	1.000	0.309	.034	18	view →
ACC	OS	Tertile	II,III,IV	0.149	0.657	.037	9	view →
KIRP	OS	Tertile	All	0.324	0.738	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SIGLEC24P–KIRC (OS)

Open the KIRC breakdown →