SHROOM4

Across TCGA cell cohorts, SHROOM4 mutation is significantly associated with the RNA expression of many other genes, with 152 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHROOM4-associated genes across cancer lineages are ACP4, PABPC1L2B, and HHLA1. Each is linked with SHROOM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHROOM4-to-partner and partner-to-SHROOM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACP4 grouped by SHROOM4-low versus SHROOM4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM4→partner) and Y-score (partner→SHROOM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ACP4 →	+0.050	+4.295	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	PABPC1L2B →	+0.099	+4.736	.009	.009	3	2
BLOOD_Leukemia	HHLA1 →	+0.011	+4.551	<.001	.004	3	2
BLOOD_Leukemia	NXPE4 →	+0.020	+4.276	<.001	.007	3	2
LARGE_INTESTINE	F13B →	+0.044	+2.827	.009	.002	3	2
LUNG_NSCLC_LUAD	OR10Q1 →	+0.041	+3.604	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 152 associations by consensus.

ACP4 by SHROOM4 expression — SOFT_TISSUE

Explore this box plot interactively →