SHQ1

Across TCGA patient cohorts, SHQ1 mutation is significantly associated with the RNA expression of many other genes, with 1,292 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHQ1-associated genes across cancer lineages are SNORA10B, ATP6V1G1P3, and OR5M4P. Each is linked with SHQ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHQ1-to-partner and partner-to-SHQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORA10B grouped by SHQ1-low versus SHQ1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHQ1→partner) and Y-score (partner→SHQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SNORA10B →	+0.433	+2.945	.005	.007	3	2
STAD	ATP6V1G1P3 →	+0.275	+3.997	.001	.001	3	2
BLCA	OR5M4P →	+0.055	+6.618	<.001	.001	3	2
CESC	TTTY12 →	+0.060	+5.812	<.001	.003	3	2
UCEC	GPR180 →	+0.567	+3.483	.002	.002	3	2
UCEC	DCK →	+0.755	+3.459	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,292 associations by consensus.

SNORA10B by SHQ1 expression — STAD

Explore this box plot interactively →