SHQ1

Across TCGA pan-cancer cohorts, SHQ1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SHQ1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SHQ1 RNA is repressed in tumor relative to normal tissue. In most cancer types SHQ1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and STAD are the cancer types where SHQ1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHQ1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.772	<.001	11	view →
LIHC	Male	II,III,IV	+0.953	<.001	9	view →
STAD	Male	II,III,IV	+0.795	<.001	8	view →
COAD	Male	All	+0.499	<.001	8	view →
BLCA	All	III,IV	+0.614	<.001	7	view →
BRCA	All	II,III,IV	+0.433	<.001	6	view →
CHOL	Male	All	+1.175	<.001	4	view →
LUAD	All	All	+0.193	.003	4	view →
READ	All	III,IV	+0.640	.024	3	view →
KICH	All	All	−0.363	.040	1	view →
KIRC	Male	II,III,IV	−0.199	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SHQ1–THCA

Open the THCA breakdown →