SHQ1

Across TCGA pan-cancer cohorts, SHQ1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated SHQ1 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SHQ1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SHQ1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and READ show a favorable association.

BRCA, LGG, and READ are the cancer types where SHQ1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	IV	0.813	0.343	.004	63	view →
LGG	OS	Median	All	0.365	0.546	<.001	53	view →
READ	OS	Tertile	All	1.000	0.319	<.001	50	view →
CESC	OS	Quartile	IV	0.095	0.681	.004	42	view →
LIHC	DFS	Quartile	All	0.413	0.615	<.001	38	view →
KIRC	DFS	Tertile	All	0.756	0.498	.004	36	view →
KICH	DFS	Median	II,III,IV	0.565	0.925	.003	23	view →
SARC	DFS	Quartile	All	0.170	0.624	<.001	22	view →
COAD	OS	Quartile	All	0.912	0.810	.008	16	view →
UCS	DFS	Tertile	II,III,IV	0.540	0.156	.011	14	view →
LUAD	DFS	Tertile	III,IV	0.223	0.521	.006	14	view →
UVM	OS	Quartile	All	0.869	0.558	.018	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

SHQ1–BRCA (OS)

Open the BRCA breakdown →