SHQ1

Across TCGA cell cohorts, SHQ1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,944 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SHQ1-associated GO terms across cancer lineages are DNA-templated transcription elongation, Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and DNA replication initiation. Each is linked with SHQ1 in more than 14 cancer types. Because this analysis shows association rather than direction, both SHQ1-to-partner and partner-to-SHQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription elongation grouped by SHQ1-low versus SHQ1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHQ1→partner) and Y-score (partner→SHQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DNA-templated transcription elongation →	+0.102	+0.892	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.149	+0.676	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.164	+0.880	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Cell cycle checkpoint signaling →	+0.086	+0.714	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Spindle assembly →	+0.082	+0.649	.001	<.001	3	12
SKIN	Positive regulation of chromosome segregation →	+0.114	+0.804	.002	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,944 associations by consensus.

DNA-templated transcription elongation by SHQ1 expression — OVARY

Explore this box plot interactively →