Across TCGA cell cohorts, SHPK mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHPK-associated genes across cancer lineages are TAAR6, SSX7, and GAPDHS. Each is linked with SHPK in more than 1 cancer types. Because this analysis shows association rather than direction, both SHPK-to-partner and partner-to-SHPK results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHPK→partner) and Y-score (partner→SHPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TAAR6 →	+0.021	+4.794	<.001	.001	3	1
STOMACH	SSX7 →	+0.325	+4.285	<.001	.007	3	1
LARGE_INTESTINE	GAPDHS →	+0.065	+3.626	<.001	.006	3	1
LARGE_INTESTINE	SLC17A1 →	+0.036	+2.878	.001	.009	3	1
LARGE_INTESTINE	BPIFB6 →	+0.014	+3.700	<.001	.009	3	1
LARGE_INTESTINE	ACER1 →	+0.138	+4.408	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

SHPK survival (RNA) · tumor vs normal (RNA) · all SHPK data types