Across TCGA cell cohorts, SHOX mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SHOX-associated genes across cancer lineages are PPIAL4F, GZMK, and KRTAP2-4. Each is linked with SHOX in more than 1 cancer types. Because this analysis shows association rather than direction, both SHOX-to-partner and partner-to-SHOX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOX→partner) and Y-score (partner→SHOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PPIAL4F →	+0.094	+4.930	<.001	.008	3	2
BLOOD_Leukemia	GZMK →	+0.414	+4.037	.008	.004	3	2
SOFT_TISSUE	KRTAP2-4 →	+0.147	+4.930	<.001	.008	3	1
SOFT_TISSUE	TARM1 →	+0.024	+5.369	.009	.004	3	1
STOMACH	TRIM49D2 →	+0.030	+4.285	<.001	.007	3	1
LARGE_INTESTINE	ACSM6 →	+0.020	+4.169	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

SHOX survival (RNA) · tumor vs normal (RNA) · all SHOX data types