SHISA8

Across TCGA patient cohorts, SHISA8 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,875 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHISA8-associated proteins across cancer lineages are CARMIL2_S1381, ZBTB40_S728, and SEPTIN6. Each is linked with SHISA8 in more than 4 cancer types. Because this analysis shows association rather than direction, both SHISA8-to-partner and partner-to-SHISA8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHISA8 versus CARMIL2_S1381 in GBM, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA8→partner) and Y-score (partner→SHISA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CARMIL2_S1381 →	+0.839	+0.457	<.001	<.001	3	5
LUAD	ZBTB40_S728 →	+0.537	+0.227	.005	.003	3	3
GBM	SEPTIN6 →	+0.414	+0.471	<.001	.003	3	3
GBM	SEPTIN6_S388 →	+1.005	+0.706	<.001	<.001	3	3
GBM	SHC1 →	-0.435	-0.381	<.001	.002	3	3
HNSC	STRBP →	+0.383	+0.344	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,875 associations by consensus.

SHISA8 vs CARMIL2_S1381 — GBM

Explore this scatter interactively →