SHISA8

Across TCGA pan-cancer cohorts, SHISA8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SHISA8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SHISA8 RNA is repressed in tumor relative to normal tissue. In most cancer types SHISA8 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, LUAD, and BRCA are the cancer types where SHISA8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHISA8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	−0.476	<.001	8	view →
LUAD	Female	II,III,IV	+0.222	.001	6	view →
BRCA	Female	All	+0.162	<.001	6	view →
KIRC	Male	III,IV	−0.150	<.001	5	view →
LIHC	All	All	+0.122	<.001	5	view →
LUSC	All	All	+0.388	<.001	4	view →
BLCA	Female	III,IV	−0.448	.031	3	view →
PRAD	All	All	+0.749	<.001	2	view →
COAD	All	II,III,IV	−0.161	.006	2	view →
CHOL	All	All	+0.142	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SHISA8–KIRP

Open the KIRP breakdown →