SHISA8

Across TCGA pan-cancer cohorts, SHISA8 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SHISA8 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SHISA8 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SHISA8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UVM, and UCEC are the cancer types where SHISA8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.751	0.544	<.001	133	view →
UVM	OS	Median	All	0.431	0.831	<.001	75	view →
UCEC	OS	Median	All	0.791	0.555	<.001	74	view →
LUSC	DFS	Quartile	II,III,IV	0.787	0.326	.001	42	view →
ACC	DFS	Tertile	All	0.235	0.668	.001	39	view →
STAD	DFS	Tertile	All	0.703	0.380	.003	36	view →
ESCA	DFS	Quartile	II,III,IV	0.731	0.411	<.001	33	view →
UCS	OS	Tertile	IV	0.205	1.000	.024	30	view →
CESC	OS	Tertile	All	0.863	0.704	.002	30	view →
CHOL	OS	Median	III,IV	1.000	0.286	.008	18	view →
PAAD	OS	Tertile	All	0.593	0.283	.012	18	view →
SKCM	OS	Median	III,IV	0.838	0.595	.004	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SHISA8–HNSC (DFS)

Open the HNSC breakdown →