SHISA8

Across TCGA cell cohorts, SHISA8 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,644 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SHISA8-associated GO terms across cancer lineages are Regulation of DNA repair, Positive regulation of DNA metabolic process, and Protein-DNA complex organization. Each is linked with SHISA8 in more than 8 cancer types. Because this analysis shows association rather than direction, both SHISA8-to-partner and partner-to-SHISA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by SHISA8-low versus SHISA8-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA8→partner) and Y-score (partner→SHISA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of DNA repair →	+0.032	+0.048	.001	.005	3	9
SOFT_TISSUE	Positive regulation of DNA metabolic process →	+0.058	+0.352	<.001	.003	3	9
LIVER	Protein-DNA complex organization →	+0.068	+0.189	<.001	<.001	3	9
BONE	Positive regulation of transmembrane transport →	-0.069	-0.177	.002	.003	3	8
LARGE_INTESTINE	P-body assembly →	+0.061	+0.183	.002	.007	3	8
OESOPHAGUS	Nuclear export →	+0.084	+0.302	<.001	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,644 associations by consensus.

Regulation of DNA repair by SHISA8 expression — CNS

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