Across TCGA cell cohorts, SHISA6 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SHISA6-associated genes across cancer lineages are GAGE12F, PAGE3, and GAGE10. Each is linked with SHISA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA6-to-partner and partner-to-SHISA6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA6→partner) and Y-score (partner→SHISA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GAGE12F →	+1.263	+4.643	.002	.008	3	2
BLOOD_Leukemia	PAGE3 →	+0.066	+3.969	<.001	.009	3	2
BLOOD_Leukemia	GAGE10 →	+0.074	+3.450	<.001	.004	3	2
LUNG_NSCLC_LUSC	OR1L3 →	+0.060	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	NLRP8 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	FAM47B →	+0.036	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

SHISA6 survival (RNA) · tumor vs normal (RNA) · all SHISA6 data types