SHD

Across TCGA patient cohorts, SHD mutation is significantly associated with the RNA expression of many other genes, with 545 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHD-associated genes across cancer lineages are DEFB117, MTND6P16, and DOHH. Each is linked with SHD in more than 1 cancer types. Because this analysis shows association rather than direction, both SHD-to-partner and partner-to-SHD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB117 grouped by SHD-low versus SHD-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHD→partner) and Y-score (partner→SHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	DEFB117 →	+0.213	+4.647	.002	.007	3	2
LIHC	MTND6P16 →	+0.106	+4.758	<.001	.006	3	2
SKCM	DOHH →	+0.556	+3.478	.002	.002	3	2
SKCM	LRRC43 →	-0.646	-3.427	.002	.005	3	2
UCEC	CENPU →	+0.890	+3.617	.001	.001	3	2
BRCA	MIR298 →	+0.702	+4.232	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 545 associations by consensus.

DEFB117 by SHD expression — LIHC

Explore this box plot interactively →