SHD

Across TCGA pan-cancer cohorts, SHD RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SHD data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SHD RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SHD expression acts as an unfavorable survival marker, although some lineages such as CESC and KICH show a favorable association.

CESC, ACC, and KICH are the cancer types where SHD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.816	0.660	<.001	114	view →
ACC	DFS	Median	All	0.404	0.758	<.001	89	view →
KICH	OS	Median	All	1.000	0.725	<.001	69	view →
BLCA	DFS	Quartile	All	0.768	0.480	.007	57	view →
LGG	OS	Median	All	0.532	0.352	<.001	54	view →
SKCM	OS	Tertile	II,III,IV	0.538	0.251	<.001	49	view →
READ	OS	Tertile	II,III,IV	0.811	0.970	.004	40	view →
BRCA	DFS	Median	All	0.601	0.472	.001	36	view →
KIRP	DFS	Median	IV	0.595	0.037	.001	30	view →
ESCA	OS	Median	All	0.647	1.000	.015	24	view →
UVM	OS	Tertile	All	0.420	0.853	.002	23	view →
COAD	OS	Quartile	All	0.673	0.897	.007	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SHD–CESC (DFS)

Open the CESC breakdown →