SHCBP1L

Across TCGA patient cohorts, SHCBP1L mutation is significantly associated with the RNA expression of many other genes, with 3,606 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHCBP1L-associated genes across cancer lineages are RNU6-241P, MTND5P31, and UHRF1. Each is linked with SHCBP1L in more than 2 cancer types. Because this analysis shows association rather than direction, both SHCBP1L-to-partner and partner-to-SHCBP1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-241P grouped by SHCBP1L-low versus SHCBP1L-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHCBP1L→partner) and Y-score (partner→SHCBP1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-241P →	+0.108	+4.824	<.001	.002	3	3
CESC	MTND5P31 →	+0.018	+5.144	<.001	.003	3	2
UCEC	UHRF1 →	+0.864	+2.654	<.001	<.001	3	2
BLCA	MRPS15P1 →	+0.080	+4.238	.006	.008	3	2
BLCA	FRG2GP →	+0.211	+4.788	<.001	.006	3	2
SKCM	FAM177A1 →	+0.463	+2.706	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,606 associations by consensus.

RNU6-241P by SHCBP1L expression — COAD

Explore this box plot interactively →