SHCBP1L

Across TCGA pan-cancer cohorts, SHCBP1L RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SHCBP1L’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SHCBP1L RNA is repressed in tumor relative to normal tissue. In most cancer types SHCBP1L is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUAD are the cancer types where SHCBP1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHCBP1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	III,IV	−0.032	.016	2	view →
KICH	All	All	−0.013	.009	2	view →
LUAD	All	II,III,IV	+0.010	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SHCBP1L–THCA

Open the THCA breakdown →