SHCBP1L

Across TCGA pan-cancer cohorts, SHCBP1L RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SHCBP1L data layer compared with 9 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SHCBP1L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHCBP1L expression acts as an unfavorable survival marker, although some lineages such as CESC and HNSC show a favorable association.

KIRC, CESC, and HNSC are the cancer types where SHCBP1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.708	0.851	.001	96	view →
CESC	OS	Tertile	All	0.738	0.496	.001	54	view →
HNSC	DFS	Tertile	All	0.786	0.669	.005	54	view →
ACC	OS	Tertile	III,IV	0.390	0.821	<.001	39	view →
LUSC	DFS	Tertile	All	0.316	0.428	.010	26	view →
READ	DFS	Tertile	All	0.970	0.776	.005	21	view →
CHOL	DFS	Tertile	II,III,IV	1.000	0.147	.041	18	view →
UCEC	OS	Median	II,III,IV	0.796	0.881	.016	14	view →
THYM	DFS	Median	III,IV	1.000	0.402	.004	13	view →
LIHC	OS	Tertile	III,IV	0.181	0.396	.013	9	view →
PCPG	OS	Tertile	All	0.772	0.981	.011	9	view →
LGG	DFS	Quartile	All	0.761	0.874	.015	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SHCBP1L–KIRC (DFS)

Open the KIRC breakdown →