SHCBP1L

Across TCGA patient cohorts, SHCBP1L mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHCBP1L-associated genes across cancer lineages are p38-MAPK_pT180_Y182, P-Cadherin, and Shc_pY317. Each is linked with SHCBP1L in more than 1 cancer types. Because this analysis shows association rather than direction, both SHCBP1L-to-partner and partner-to-SHCBP1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by SHCBP1L-low versus SHCBP1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHCBP1L→partner) and Y-score (partner→SHCBP1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.515	-2.502	<.001	.001	3	2
UCEC	P-Cadherin →	-0.107	-2.000	.029	.029	3	2
UCEC	Shc_pY317 →	-0.195	-2.087	<.001	.005	3	2
UCEC	eEF2 →	+0.331	+2.584	.006	.010	3	1
UCEC	EGFR_pY1068 →	-0.306	-2.137	<.001	.001	3	1
UCEC	eIF4E →	+0.196	+2.713	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

p38-MAPK_pT180_Y182 by SHCBP1L expression — UCEC

Explore this box plot interactively →