SHCBP1L

Across TCGA cell cohorts, SHCBP1L RNA expression is significantly associated with the go_rna of many other GO terms, with 907 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SHCBP1L-associated GO terms across cancer lineages are Regulation of mRNA 3'-end processing, Regulation of interleukin-18 production, and Negative regulation of nucleocytoplasmic transport. Each is linked with SHCBP1L in more than 2 cancer types. Because this analysis shows association rather than direction, both SHCBP1L-to-partner and partner-to-SHCBP1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA 3'-end processing grouped by SHCBP1L-low versus SHCBP1L-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHCBP1L→partner) and Y-score (partner→SHCBP1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of mRNA 3'-end processing →	+0.079	+0.016	<.001	.005	3	3
BLOOD_Lymphoma	Regulation of interleukin-18 production →	-0.180	-0.015	<.001	.004	3	3
BLOOD_Lymphoma	Negative regulation of nucleocytoplasmic transport →	+0.053	+0.012	.009	.004	3	3
BLOOD_Leukemia	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.072	+0.007	<.001	.005	3	2
BLOOD_Lymphoma	Protein homooligomerization →	-0.023	-0.011	.003	.006	3	2
BLOOD_Leukemia	Transcription initiation at RNA polymerase II promoter →	+0.043	+0.007	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 907 associations by consensus.

Regulation of mRNA 3'-end processing by SHCBP1L expression — BLOOD_Lymphoma

Explore this box plot interactively →