SHCBP1L

Across TCGA cell cohorts, SHCBP1L mutation is significantly associated with the RNA expression of many other genes, with 425 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHCBP1L-associated genes across cancer lineages are MAGEB5, CXorf51A, and GCAT. Each is linked with SHCBP1L in more than 1 cancer types. Because this analysis shows association rather than direction, both SHCBP1L-to-partner and partner-to-SHCBP1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by SHCBP1L-low versus SHCBP1L-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHCBP1L→partner) and Y-score (partner→SHCBP1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CXorf51A →	+0.066	+4.643	<.001	.008	3	1
LARGE_INTESTINE	GCAT →	+1.517	+3.459	<.001	.001	3	1
LARGE_INTESTINE	ANKRD54 →	+0.465	+3.067	.002	.009	3	1
LARGE_INTESTINE	EIF3L →	+0.457	+3.237	.005	.003	3	1
LARGE_INTESTINE	DEPDC5 →	+0.516	+3.321	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 425 associations by consensus.

MAGEB5 by SHCBP1L expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →