SHARPIN

Across TCGA patient cohorts, SHARPIN protein abundance is significantly associated with the RNA expression of many other genes, with 11,040 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SHARPIN-associated genes across cancer lineages are DYNC1I1, RIMKLA, and DLX6-AS1. Each is linked with SHARPIN in more than 3 cancer types. Because this analysis shows association rather than direction, both SHARPIN-to-partner and partner-to-SHARPIN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHARPIN versus DYNC1I1 in UCEC, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHARPIN→partner) and Y-score (partner→SHARPIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DYNC1I1 →	-1.462	-0.234	<.001	.004	3	4
UCEC	RIMKLA →	-0.902	-0.199	<.001	<.001	3	4
UCEC	DLX6-AS1 →	-1.054	-0.186	.008	.008	3	4
HNSC	PCYT1B →	-0.914	-0.220	<.001	.001	3	4
HNSC	LMO4 →	-0.701	-0.237	.001	.001	3	4
HNSC	OCA2 →	-0.976	-0.267	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,040 associations by consensus.

SHARPIN vs DYNC1I1 — UCEC

Explore this scatter interactively →