SHARPIN

Across TCGA patient cohorts, SHARPIN mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible SHARPIN-associated genes across cancer lineages are RNA5SP146, MIR920, and STAU2P1. Each is linked with SHARPIN in more than 1 cancer types. Because this analysis shows association rather than direction, both SHARPIN-to-partner and partner-to-SHARPIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP146 grouped by SHARPIN-low versus SHARPIN-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHARPIN→partner) and Y-score (partner→SHARPIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP146 →	+0.566	+5.409	<.001	.005	3	2
UCEC	MIR920 →	+0.603	+3.456	.003	<.001	3	2
UCEC	STAU2P1 →	+0.220	+2.573	<.001	.009	3	2
UCEC	LINC01758 →	+0.265	+2.812	<.001	.008	3	2
UCEC	RN7SL354P →	+0.335	+2.695	<.001	.007	3	2
BRCA	MIR3118-3 →	+0.819	+9.471	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

RNA5SP146 by SHARPIN expression — BRCA

Explore this box plot interactively →