SHARPIN

Across TCGA patient cohorts, SHARPIN mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. OV shows the largest number of these associations.

The most reproducible SHARPIN-associated genes across cancer lineages are CD4+ Tem and Osteoblast. Each is linked with SHARPIN in more than 1 cancer types. Because this analysis shows association rather than direction, both SHARPIN-to-partner and partner-to-SHARPIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ Tem grouped by SHARPIN-low versus SHARPIN-high in OV.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHARPIN→partner) and Y-score (partner→SHARPIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CD4+ Tem →	+0.030	+5.930	<.001	.032	3	1
UCEC	Osteoblast →	-0.060	-2.978	.022	.037	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD4+ Tem by SHARPIN expression — OV

Explore this box plot interactively →