SH3TC1

Across TCGA patient cohorts, SH3TC1 mutation is significantly associated with the RNA expression of many other genes, with 4,425 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3TC1-associated genes across cancer lineages are RPL36AL, ZNF57, and C15orf61. Each is linked with SH3TC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SH3TC1-to-partner and partner-to-SH3TC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL36AL grouped by SH3TC1-low versus SH3TC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3TC1→partner) and Y-score (partner→SH3TC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL36AL →	+0.385	+3.237	.005	.008	3	4
UCEC	ZNF57 →	+0.355	+1.898	<.001	<.001	3	4
UCEC	C15orf61 →	+0.373	+2.090	<.001	<.001	3	4
COAD	SLC19A3 →	-0.946	-3.564	.001	.002	3	4
UCEC	NDUFAF5 →	+0.220	+1.978	.004	.002	3	4
UCEC	ETHE1 →	+0.437	+2.010	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,425 associations by consensus.

RPL36AL by SH3TC1 expression — COAD

Explore this box plot interactively →