SH3TC1

Across TCGA pan-cancer cohorts, SH3TC1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SH3TC1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SH3TC1 RNA is repressed in tumor relative to normal tissue. In most cancer types SH3TC1 is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

KIRP, COAD, and HNSC are the cancer types where SH3TC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SH3TC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	−1.325	<.001	9	view →
COAD	Female	All	+0.681	<.001	9	view →
HNSC	Female	III,IV	+1.446	<.001	7	view →
STAD	All	All	+0.982	<.001	6	view →
THCA	All	All	−0.261	.006	6	view →
BRCA	Female	All	+0.213	.009	4	view →
LIHC	Female	II,III,IV	+0.974	.001	3	view →
LUSC	All	All	−0.480	.007	3	view →
KIRC	Female	All	+0.466	<.001	3	view →
CHOL	All	All	+0.778	.007	2	view →
READ	All	All	+0.697	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SH3TC1–KIRP

Open the KIRP breakdown →