SH3BP1

Across TCGA patient cohorts, SH3BP1 mutation is significantly associated with the RNA expression of many other genes, with 964 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3BP1-associated genes across cancer lineages are SYPL1P1, RNA5SP116, and RN7SL255P. Each is linked with SH3BP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH3BP1-to-partner and partner-to-SH3BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYPL1P1 grouped by SH3BP1-low versus SH3BP1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP1→partner) and Y-score (partner→SH3BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SYPL1P1 →	+0.154	+3.628	<.001	.006	3	3
UCEC	RNA5SP116 →	+0.174	+4.253	<.001	.004	3	3
BLCA	RN7SL255P →	+0.359	+4.049	<.001	.003	3	2
CESC	RPS29P22 →	+0.250	+3.654	<.001	<.001	3	2
CESC	TGFB3-AS1 →	+0.273	+3.736	<.001	.002	3	2
BLCA	BNIP3P20 →	+0.116	+3.266	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 964 associations by consensus.

SYPL1P1 by SH3BP1 expression — BLCA

Explore this box plot interactively →