SH3BP1

Across TCGA patient cohorts, SH3BP1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3BP1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Shc_pY317, and EGFR_pY1068. Each is linked with SH3BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BP1-to-partner and partner-to-SH3BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by SH3BP1-low versus SH3BP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP1→partner) and Y-score (partner→SH3BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.624	-3.169	.004	.019	3	2
UCEC	Shc_pY317 →	-0.240	-3.321	.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.315	-3.584	.009	.002	3	1
UCEC	IGFBP2 →	-0.871	-2.459	.005	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.193	-3.169	.017	.019	3	1
UCEC	p62 Lck ligand →	+0.405	+2.459	.010	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

p38-MAPK_pT180_Y182 by SH3BP1 expression — UCEC

Explore this box plot interactively →