SH3BP1

Across TCGA cell cohorts, SH3BP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,903 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3BP1-associated GO terms across cancer lineages are Cellular response to alcohol, Establishment or maintenance of epithelial cell apical/basal polarity, and Establishment or maintenance of apical/basal cell polarity. Each is linked with SH3BP1 in more than 12 cancer types. Because this analysis shows association rather than direction, both SH3BP1-to-partner and partner-to-SH3BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to alcohol grouped by SH3BP1-low versus SH3BP1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP1→partner) and Y-score (partner→SH3BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Cellular response to alcohol →	+0.091	+1.768	.003	.003	3	13
LIVER	Establishment or maintenance of epithelial cell apical/basal polarity →	+0.129	+1.666	.006	.002	2	12
OESOPHAGUS	Establishment or maintenance of apical/basal cell polarity →	+0.131	+1.255	<.001	.007	3	11
OESOPHAGUS	Establishment or maintenance of bipolar cell polarity →	+0.131	+1.255	<.001	.007	3	11
LUNG_NSCLC_LUAD	Negative regulation of mRNA splicing, via spliceosome →	+0.066	+1.222	.003	<.001	3	10
OESOPHAGUS	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.218	+1.595	.002	.009	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,903 associations by consensus.

Cellular response to alcohol by SH3BP1 expression — OESOPHAGUS

Explore this box plot interactively →