Across TCGA patient cohorts, SH3BGRL2 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3BGRL2-associated genes across cancer lineages are RNA5SP414, RNA5SP411, and MIR6509. Each is linked with SH3BGRL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BGRL2-to-partner and partner-to-SH3BGRL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BGRL2→partner) and Y-score (partner→SH3BGRL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.796	+3.577	<.001	<.001	3	1
UCEC	RNA5SP411 →	+1.343	+2.715	.001	.006	3	1
UCEC	MIR6509 →	+0.608	+2.599	.001	.009	3	1
UCEC	CICP28 →	+0.039	+3.029	<.001	.005	3	1
UCEC	MIR8077 →	+0.289	+4.069	<.001	.008	3	1
HNSC	DEFB107B →	+0.104	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

Exploration

SH3BGRL2 survival (RNA) · tumor vs normal (RNA) · all SH3BGRL2 data types