SH2D3C

Across TCGA patient cohorts, SH2D3C mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D3C-associated genes across cancer lineages are TFRC, Cyclin-B1, and ASNS. Each is linked with SH2D3C in more than 2 cancer types. Because this analysis shows association rather than direction, both SH2D3C-to-partner and partner-to-SH2D3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by SH2D3C-low versus SH2D3C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D3C→partner) and Y-score (partner→SH2D3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.569	+1.440	.001	.024	3	3
UCEC	Cyclin-B1 →	+0.646	+2.222	<.001	.009	3	3
COAD	ASNS →	+0.602	+3.008	.003	.019	3	2
COAD	Caspase-7-cleavedD198 →	+2.057	+3.008	<.001	.019	3	2
UCEC	eEF2 →	+0.379	+1.440	.002	.024	3	2
UCEC	EGFR_pY1068 →	-0.308	-3.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

TFRC by SH2D3C expression — UCEC

Explore this box plot interactively →