SH2D3C

Across TCGA pan-cancer cohorts, SH2D3C RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SH2D3C data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SH2D3C RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SH2D3C expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRP, and KIRC are the cancer types where SH2D3C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.418	0.226	<.001	124	view →
KIRP	DFS	Quartile	II,III,IV	0.398	0.824	<.001	102	view →
KIRC	DFS	Median	All	0.743	0.517	<.001	84	view →
UVM	OS	Median	All	0.419	0.790	.001	76	view →
PAAD	DFS	Tertile	All	0.471	0.283	.001	43	view →
SCLC	OS	Median	III,IV	0.178	0.458	.007	36	view →
CESC	DFS	Tertile	II,III,IV	0.892	0.630	<.001	32	view →
MESO	OS	Median	II,III,IV	0.285	0.499	.004	31	view →
SARC	OS	Tertile	All	0.824	0.644	.001	29	view →
LAML	DFS	Tertile	All	0.182	0.455	.004	28	view →
THCA	DFS	Quartile	All	0.954	0.789	.004	23	view →
SKCM	DFS	Median	II,III,IV	0.695	0.475	.003	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SH2D3C–HNSC (DFS)

Open the HNSC breakdown →