SH2D3C

Across TCGA pan-cancer cohorts, SH2D3C RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SH2D3C’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SH2D3C RNA is repressed in tumor relative to normal tissue. In most cancer types SH2D3C is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LUAD, KICH, and KIRC are the cancer types where SH2D3C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SH2D3C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−2.393	<.001	11	view →
KICH	Male	II,III,IV	−1.737	<.001	11	view →
KIRC	Female	All	+1.327	<.001	11	view →
KIRP	Male	All	−1.511	<.001	9	view →
HNSC	Female	III,IV	+1.135	<.001	9	view →
LUSC	Female	II,III,IV	−2.995	<.001	8	view →
LIHC	Female	II,III,IV	+1.244	<.001	8	view →
UCEC	All	All	−1.750	<.001	6	view →
BRCA	All	II,III,IV	−0.759	<.001	6	view →
STAD	All	II,III,IV	+0.771	.004	4	view →
THCA	All	IV	−1.165	.004	2	view →
CHOL	All	All	+1.146	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SH2D3C–LUAD

Open the LUAD breakdown →