SH2D3C

Across TCGA cell cohorts, SH2D3C RNA expression is significantly associated with the go_rna of many other GO terms, with 3,928 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH2D3C-associated GO terms across cancer lineages are Response to starvation, Response to amino acid starvation, and Regulation of TORC1 signaling. Each is linked with SH2D3C in more than 9 cancer types. Because this analysis shows association rather than direction, both SH2D3C-to-partner and partner-to-SH2D3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to starvation grouped by SH2D3C-low versus SH2D3C-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D3C→partner) and Y-score (partner→SH2D3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Response to starvation →	+0.068	+0.590	.001	.003	2	10
BLOOD_Myeloma	Response to amino acid starvation →	+0.052	+1.112	.003	<.001	3	9
STOMACH	Regulation of TORC1 signaling →	+0.098	+0.519	<.001	.003	3	9
URINARY_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.072	+0.290	.005	.007	2	10
URINARY_TRACT	Regulation of myoblast fusion →	+0.076	+0.303	.002	.005	2	9
KIDNEY	Negative regulation of myoblast fusion →	+0.093	+0.145	.002	.009	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,928 associations by consensus.

Response to starvation by SH2D3C expression — OESOPHAGUS

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