SH2D3C

Across TCGA cell cohorts, SH2D3C mutation is significantly associated with the RNA expression of many other genes, with 838 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH2D3C-associated genes across cancer lineages are METTL4, TLCD3A, and CCDC134. Each is linked with SH2D3C in more than 2 cancer types. Because this analysis shows association rather than direction, both SH2D3C-to-partner and partner-to-SH2D3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL4 grouped by SH2D3C-low versus SH2D3C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D3C→partner) and Y-score (partner→SH2D3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	METTL4 →	+0.527	+2.158	.002	.004	3	3
LARGE_INTESTINE	TLCD3A →	+0.677	+3.169	.001	.009	3	3
LARGE_INTESTINE	CCDC134 →	+0.858	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	CBY1 →	+0.656	+3.482	<.001	<.001	3	2
LARGE_INTESTINE	CNIH1 →	+0.386	+2.244	.008	.003	3	2
LARGE_INTESTINE	UFSP2 →	+0.430	+3.082	.007	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 838 associations by consensus.

METTL4 by SH2D3C expression — LARGE_INTESTINE

Explore this box plot interactively →