SH2D3A

Across TCGA cell cohorts, SH2D3A mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SH2D3A-associated genes across cancer lineages are CMA1, GPR148, and OR10K2. Each is linked with SH2D3A in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D3A-to-partner and partner-to-SH2D3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CMA1 grouped by SH2D3A-low versus SH2D3A-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D3A→partner) and Y-score (partner→SH2D3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CMA1 →	+0.041	+4.963	<.001	.001	3	2
BREAST	GPR148 →	+0.062	+4.672	<.001	.002	3	1
BREAST	OR10K2 →	+0.047	+4.781	<.001	.003	3	1
BREAST	OR10T2 →	+0.137	+4.781	<.001	.003	3	1
SKIN	CHRNB3 →	+0.011	+4.467	<.001	.004	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

CMA1 by SH2D3A expression — BREAST

Explore this box plot interactively →