SH2D3A

Across TCGA pan-cancer cohorts, SH2D3A RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SH2D3A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SH2D3A RNA is repressed in tumor relative to normal tissue. In most cancer types SH2D3A is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where SH2D3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SH2D3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.134	<.001	12	view →
KICH	Male	II,III,IV	−2.006	<.001	10	view →
THCA	All	III,IV	+0.547	<.001	10	view →
HNSC	Male	All	+0.959	<.001	8	view →
COAD	All	All	+0.527	<.001	8	view →
STAD	All	All	+1.016	<.001	6	view →
LIHC	All	III,IV	+0.471	.002	6	view →
LUAD	All	II,III,IV	+0.469	.001	6	view →
BLCA	All	III,IV	+1.387	.014	5	view →
CHOL	All	All	+4.044	<.001	3	view →
LUSC	Male	All	+0.493	.001	3	view →
PAAD	All	All	+1.307	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SH2D3A–KIRC

Open the KIRC breakdown →