SH2B3

Across TCGA patient cohorts, SH2B3 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,082 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SH2B3-associated proteins across cancer lineages are PLEKHO2, STAB1, and GIMAP8. Each is linked with SH2B3 in more than 8 cancer types. Because this analysis shows association rather than direction, both SH2B3-to-partner and partner-to-SH2B3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH2B3 versus PLEKHO2 in HNSC, with a Pearson correlation of 0.29.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B3→partner) and Y-score (partner→SH2B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PLEKHO2 →	+0.397	+0.555	<.001	<.001	3	9
GBM	STAB1 →	+0.456	+0.407	<.001	<.001	3	9
HNSC	GIMAP8 →	+0.645	+0.602	<.001	<.001	3	9
GBM	RENBP →	+0.729	+0.496	<.001	<.001	3	8
GBM	ELMO1 →	+0.572	+0.610	<.001	<.001	3	8
UCEC	FNBP1 →	+0.414	+0.371	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,082 associations by consensus.

SH2B3 vs PLEKHO2 — HNSC

Explore this scatter interactively →