SH2B3

Across TCGA patient cohorts, SH2B3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,378 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SH2B3-associated genes across cancer lineages are RBBP8, TBCCD1, and SLC6A8. Each is linked with SH2B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2B3-to-partner and partner-to-SH2B3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH2B3 versus RBBP8 in LSCC, with a Pearson correlation of -0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B3→partner) and Y-score (partner→SH2B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RBBP8 →	-0.702	-0.525	.006	<.001	3	2
LSCC	TBCCD1 →	-0.798	-0.439	.001	<.001	3	2
LSCC	SLC6A8 →	-1.497	-0.374	.002	.004	3	2
GBM	IGSF3 →	-1.665	-0.714	.005	.002	3	2
LSCC	EIF2B5 →	-0.819	-0.465	<.001	.002	3	2
LSCC	A2M →	+1.064	+0.490	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,378 associations by consensus.

SH2B3 vs RBBP8 — LSCC

Explore this scatter interactively →