SH2B3

Across TCGA cell cohorts, SH2B3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,037 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SH2B3-associated GO terms across cancer lineages are PML body organization, Negative regulation of receptor signaling pathway via STAT, and Megakaryocyte differentiation. Each is linked with SH2B3 in more than 13 cancer types. Because this analysis shows association rather than direction, both SH2B3-to-partner and partner-to-SH2B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PML body organization grouped by SH2B3-low versus SH2B3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B3→partner) and Y-score (partner→SH2B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PML body organization →	+0.245	+1.790	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Negative regulation of receptor signaling pathway via STAT →	+0.137	+1.895	<.001	<.001	3	13
URINARY_TRACT	Megakaryocyte differentiation →	+0.195	+2.212	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Negative regulation of receptor signaling pathway via JAK-STAT →	+0.115	+1.865	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Transport of virus →	+0.210	+2.164	.002	<.001	3	12
LUNG_NSCLC_LUSC	Negative regulation of small GTPase mediated signal transduction →	+0.083	+1.560	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,037 associations by consensus.

PML body organization by SH2B3 expression — LIVER

Explore this box plot interactively →