SH2B3

Across TCGA cell cohorts, SH2B3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH2B3-associated genes across cancer lineages are SCGB1D4, TCF15, and KRTAP4-4. Each is linked with SH2B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2B3-to-partner and partner-to-SH2B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1D4 grouped by SH2B3-low versus SH2B3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B3→partner) and Y-score (partner→SH2B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SCGB1D4 →	+0.130	+5.807	<.001	.001	3	1
BLOOD_Lymphoma	TCF15 →	+0.617	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-4 →	+0.024	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	S100A7A →	+0.042	+4.643	<.001	.005	3	1
LARGE_INTESTINE	IRX4 →	+0.455	+3.409	.001	.009	3	1
LARGE_INTESTINE	VAX1 →	+0.541	+3.782	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SCGB1D4 by SH2B3 expression — OVARY

Explore this box plot interactively →