SH2B2

Across TCGA cell cohorts, SH2B2 mutation is significantly associated with the RNA expression of many other genes, with 571 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH2B2-associated genes across cancer lineages are RESP18, OR2J3, and SAMM50. Each is linked with SH2B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2B2-to-partner and partner-to-SH2B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RESP18 grouped by SH2B2-low versus SH2B2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B2→partner) and Y-score (partner→SH2B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RESP18 →	+0.072	+5.169	<.001	.005	3	1
BLOOD_Lymphoma	OR2J3 →	+0.019	+4.867	<.001	.009	3	1
LARGE_INTESTINE	SAMM50 →	+0.608	+3.064	<.001	.009	3	1
LARGE_INTESTINE	TNRC6B →	+0.868	+3.212	<.001	.006	3	1
LARGE_INTESTINE	HFE →	+1.001	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CD81 →	+0.741	+3.212	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 571 associations by consensus.

RESP18 by SH2B2 expression — BREAST

Explore this box plot interactively →