SH2B2

Across TCGA pan-cancer cohorts, SH2B2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SH2B2 data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SH2B2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SH2B2 expression acts as an unfavorable survival marker, although some lineages such as SCLC and CHOL show a favorable association.

UVM, ACC, and SCLC are the cancer types where SH2B2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.353	0.914	<.001	81	view →
ACC	DFS	Quartile	All	0.296	0.767	.002	33	view →
SCLC	OS	Median	All	0.482	0.173	<.001	33	view →
KIRP	DFS	Median	All	0.862	0.955	.002	31	view →
CHOL	OS	Tertile	All	1.000	0.216	.007	30	view →
PRAD	DFS	Quartile	All	0.820	0.944	.001	30	view →
ESCA	OS	Median	II,III,IV	0.670	0.380	.001	28	view →
LIHC	DFS	Tertile	All	0.469	0.615	.006	22	view →
KIRC	OS	Quartile	All	0.761	0.865	.004	20	view →
BRCA	DFS	Median	III,IV	0.822	0.936	.001	20	view →
HNSC	DFS	Quartile	III,IV	0.444	0.159	.004	16	view →
LUSC	DFS	Quartile	II,III,IV	0.487	0.696	.014	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SH2B2–UVM (OS)

Open the UVM breakdown →