SGCE

Across TCGA patient cohorts, SGCE mutation is significantly associated with the RNA expression of many other genes, with 2,800 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGCE-associated genes across cancer lineages are RPS27P5, GAGE2E, and GTSE1-DT. Each is linked with SGCE in more than 2 cancer types. Because this analysis shows association rather than direction, both SGCE-to-partner and partner-to-SGCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS27P5 grouped by SGCE-low versus SGCE-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCE→partner) and Y-score (partner→SGCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPS27P5 →	+0.093	+3.776	<.001	.003	3	3
LUSC	GAGE2E →	+0.186	+3.059	<.001	.009	3	3
UCEC	GTSE1-DT →	+0.506	+2.327	<.001	<.001	3	2
SKCM	DUXAP3 →	+0.092	+4.292	<.001	<.001	3	2
SKCM	RN7SL563P →	+0.176	+3.623	<.001	.001	3	2
SKCM	RN7SL344P →	+0.165	+2.936	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,800 associations by consensus.

RPS27P5 by SGCE expression — SKCM

Explore this box plot interactively →