SGCE

Across TCGA pan-cancer cohorts, SGCE RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SGCE’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SGCE RNA is repressed in tumor relative to normal tissue. In most cancer types SGCE is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, COAD, and THCA are the cancer types where SGCE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SGCE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.761	<.001	9	view →
COAD	Female	II,III,IV	−1.428	<.001	9	view →
THCA	All	II,III,IV	−0.839	<.001	9	view →
BLCA	Male	IV	−3.272	<.001	8	view →
KICH	Female	II,III,IV	−2.511	<.001	7	view →
LUSC	Female	All	−1.866	<.001	7	view →
UCEC	All	All	−2.860	<.001	6	view →
BRCA	All	III,IV	−1.462	<.001	6	view →
READ	Female	All	−2.254	.014	2	view →
KIRP	All	IV	+1.342	.001	2	view →
CHOL	Male	All	+1.201	.021	2	view →
PRAD	All	All	−0.851	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SGCE–LUAD

Open the LUAD breakdown →