SGCA

Across TCGA cell cohorts, SGCA mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SGCA-associated genes across cancer lineages are OR6T1, POTEB, and MYH7. Each is linked with SGCA in more than 1 cancer types. Because this analysis shows association rather than direction, both SGCA-to-partner and partner-to-SGCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6T1 grouped by SGCA-low versus SGCA-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCA→partner) and Y-score (partner→SGCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR6T1 →	+0.052	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	POTEB →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	MYH7 →	+0.016	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR6T1 by SGCA expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →