SGCA

Across TCGA pan-cancer cohorts, SGCA RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SGCA’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SGCA RNA is repressed in tumor relative to normal tissue. In most cancer types SGCA is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LUAD, and COAD are the cancer types where SGCA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SGCA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−5.197	<.001	11	view →
LUAD	Male	III,IV	−2.156	<.001	11	view →
COAD	Male	II,III,IV	−1.771	<.001	11	view →
LUSC	Female	II,III,IV	−2.894	<.001	9	view →
HNSC	Male	All	−1.579	.009	8	view →
STAD	All	All	−1.840	<.001	7	view →
KIRP	All	All	−0.905	<.001	7	view →
UCEC	All	III,IV	−3.881	<.001	6	view →
BRCA	All	All	−0.906	<.001	6	view →
THCA	All	II,III,IV	−0.605	.006	6	view →
READ	All	All	−2.293	<.001	5	view →
KICH	All	All	−0.913	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SGCA–BLCA

Open the BLCA breakdown →